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1996 2
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2009 1
2010 1
2013 1
2014 1
2015 1
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2017 3
2018 5
2019 3
2020 8
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52 results

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Page 1
Clinical Features, Neuropathology, and Surgical Outcome in Patients With Refractory Epilepsy and Brain Somatic Variants in the SLC35A2 Gene.
Barba C, Blumcke I, Winawer MR, Hartlieb T, Kang HC, Grisotto L, Chipaux M, Bien CG, Heřmanovská B, Porter BE, Lidov HGW, Cetica V, Woermann FG, Lopez-Rivera JA, Canoll PD, Mader I, D'Incerti L, Baldassari S, Yang E, Gaballa A, Vogel H, Straka B, Macconi L, Polster T, Grant GA, Krsková L, Shin HJ, Ko A, Crino PB, Krsek P, Lee JH, Lal D, Baulac S, Poduri A, Guerrini R; SLC35A2 Study Group. Barba C, et al. Neurology. 2023 Jan 31;100(5):e528-e542. doi: 10.1212/WNL.0000000000201471. Epub 2022 Oct 28. Neurology. 2023. PMID: 36307217 Free PMC article.
Brain MRI was abnormal in all patients with EE and in 50% of those with DR-FE. ...DISCUSSION: Brain somatic SLC35A2 gene variants are associated with 2 main clinical phenotypes, EE and DR-FE, and a histopathologic diagnosis of MOGHE. ...
Brain MRI was abnormal in all patients with EE and in 50% of those with DR-FE. ...DISCUSSION: Brain somatic SLC35A2 gene varia
Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy.
Yang F, Zhang D, Jiang H, Ye J, Zhang L, Bagley SJ, Winkler J, Gong Y, Fan Y. Yang F, et al. Sci Transl Med. 2023 Feb 15;15(683):eabq3558. doi: 10.1126/scitranslmed.abq3558. Epub 2023 Feb 15. Sci Transl Med. 2023. PMID: 36791206 Free PMC article.
Chemoproteomic and structural analyses revealed that TSN interacts with Hck and Lyn to abrogate suppressive macrophage immunity. In addition, a combination of immune checkpoint blockade and TSN therapy induced regression of syngeneic GBM tumors in mice. ...
Chemoproteomic and structural analyses revealed that TSN interacts with Hck and Lyn to abrogate suppressive macrophage immunity. In a …
Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.
Saloner R, VandeVrede L, Asken BM, Paolillo EW, Gontrum EQ, Wolf A, Lario-Lago A, Milà-Alomà M, Triana-Baltzer G, Kolb HC, Dubal DB, Rabinovici GD, Miller BL, Boxer AL, Casaletto KB, Kramer JH. Saloner R, et al. Alzheimers Dement. 2024 Jan;20(1):376-387. doi: 10.1002/alz.13454. Epub 2023 Aug 28. Alzheimers Dement. 2024. PMID: 37639492 Free PMC article.
CU males exhibited similar rates of cognitive decline and brain atrophy, but these trajectories were not dependent on plasma p-tau217. ...DISCUSSION: Plasma p-tau217 may capture earlier Alzheimer's disease (AD)-related cognitive and brain atrophy hallmarks in female …
CU males exhibited similar rates of cognitive decline and brain atrophy, but these trajectories were not dependent on plasma p-tau217 …
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease.
Bellaver B, Povala G, Ferreira PCL, Ferrari-Souza JP, Leffa DT, Lussier FZ, Benedet AL, Ashton NJ, Triana-Baltzer G, Kolb HC, Tissot C, Therriault J, Servaes S, Stevenson J, Rahmouni N, Lopez OL, Tudorascu DL, Villemagne VL, Ikonomovic MD, Gauthier S, Zimmer ER, Zetterberg H, Blennow K, Aizenstein HJ, Klunk WE, Snitz BE, Maki P, Thurston RC, Cohen AD, Ganguli M, Karikari TK, Rosa-Neto P, Pascoal TA. Bellaver B, et al. Nat Med. 2023 Jul;29(7):1775-1781. doi: 10.1038/s41591-023-02380-x. Epub 2023 May 29. Nat Med. 2023. PMID: 37248300 Free PMC article.
Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation.
Quaranta DV, Weaver RR, Baumann KK, Fujimoto T, Williams LM, Kim HC, Logsdon AF, Omer M, Reed MJ, Banks WA, Erickson MA. Quaranta DV, et al. J Pharmacol Exp Ther. 2023 Jan;384(1):205-223. doi: 10.1124/jpet.122.001380. Epub 2022 Oct 30. J Pharmacol Exp Ther. 2023. PMID: 36310035 Free PMC article.
C-C motif chemokine receptor 2 (CCL2) (MCP-1) and C-C motif chemokine receptor 5 (CCL5) (RANTES) are proinflammatory chemokines that mediate neuroimmune responses to acute insults and aspects of brain injury and neurodegenerative diseases; however, a blood-to-brain
C-C motif chemokine receptor 2 (CCL2) (MCP-1) and C-C motif chemokine receptor 5 (CCL5) (RANTES) are proinflammatory chemokines that mediate …
HCK promotes glioblastoma progression by TGFbeta signaling.
Wang Z, Ying C, Zhang A, Xu H, Jiang Y, Lou M. Wang Z, et al. Biosci Rep. 2020 Jun 26;40(6):BSR20200975. doi: 10.1042/BSR20200975. Biosci Rep. 2020. PMID: 32484210 Free PMC article.
Nevertheless, the roles of HCK in glioblastoma (GBM) remain to be examined. Thus, we aimed to investigate the effects of HCK on GBM development both in vitro and in vivo, as well as the underlying mechanism. ...In addition, we also found that HCK accentuates …
Nevertheless, the roles of HCK in glioblastoma (GBM) remain to be examined. Thus, we aimed to investigate the effects of HCK o …
Exploring Cannabis and Alcohol Co-Use in Adolescents: A Narrative Review of the Evidence.
Karoly HC, Ross JM, Ellingson JM, Feldstein Ewing SW. Karoly HC, et al. J Dual Diagn. 2020 Jan-Mar;16(1):58-74. doi: 10.1080/15504263.2019.1660020. Epub 2019 Sep 13. J Dual Diagn. 2020. PMID: 31519143 Free PMC article. Review.
Thus, the acute effects of cannabis and alcohol, and the impact of co-use of cannabis and alcohol on the adolescent brain, cognitive function and subsequent psychosocial outcomes remains understudied. ...Results: Current studies of the impact of cannabis and alcohol on ado …
Thus, the acute effects of cannabis and alcohol, and the impact of co-use of cannabis and alcohol on the adolescent brain, cognitive …
Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo.
Kong X, Liao Y, Zhou L, Zhang Y, Cheng J, Yuan Z, Wang S. Kong X, et al. Front Pharmacol. 2020 Sep 15;11:581011. doi: 10.3389/fphar.2020.581011. eCollection 2020. Front Pharmacol. 2020. PMID: 33041826 Free PMC article.
However, the underlying mechanism is not known. Hence, in this study, we aimed to investigate the role of HCK in NLRP3 inflammasome activation. We demonstrated that HCK silencing inhibited NLRP3 inflammasome activation. ...Collectively, these results suggested that …
However, the underlying mechanism is not known. Hence, in this study, we aimed to investigate the role of HCK in NLRP3 inflammasome a …
Lynch Syndrome: Genomics Update and Imaging Review.
Cox VL, Saeed Bamashmos AA, Foo WC, Gupta S, Yedururi S, Garg N, Kang HC. Cox VL, et al. Radiographics. 2018 Mar-Apr;38(2):483-499. doi: 10.1148/rg.2018170075. Radiographics. 2018. PMID: 29528821 Review.
Other cancers associated with Lynch syndrome include cancers of the ovary, stomach, urothelial tract, and small bowel, and less frequently, cancers of the brain, biliary tract, pancreas, and prostate. The oncogenic tendency of Lynch syndrome stems from a set of genomic alt …
Other cancers associated with Lynch syndrome include cancers of the ovary, stomach, urothelial tract, and small bowel, and less frequently, …
52 results